Semisupervised hypergraph discriminant learning for dimensionality reduction of hyperspectral image.

Semisupervised learning is an effective technique to represent the intrinsic features of a hyperspectral image (HSI), which can reduce the cost to obtain the labeled information of samples. However, traditional semisupervised learning methods fail to consider multiple properties of an HSI, which has restricted the discriminant performance of feature representation. In this article, we introduce the hypergraph into semisupervised learning to reveal the complex multistructures of an HSI, and construct a semisupervised discriminant hypergraph learning (SSDHL) method by designing an intraclass hypergraph and an interclass graph with the labeled samples. SSDHL constructs an unsupervised hypergraph with the unlabeled samples. In addition, a total scatter matrix is used to measure the distribution of the labeled and unlabeled samples. Then, a low-dimensional projection function is constructed to compact the properties of the intraclass hypergraph and the unsupervised hypergraph, and simultaneously separate the characteristics of the interclass graph and the total scatter matrix. Finally, according to the objective function, we can obtain the projection matrix and the low-dimensional features. Experiments on three HSI data sets (Botswana, KSC, and PaviaU) show that the proposed method can achieve better classification results compared with a few state-of-the-art methods. The result indicates that SSDHL can simultaneously utilize the labeled and unlabeled samples to represent the homogeneous properties and restrain the heterogeneous characteristics of an HSI

Multi-scale diff-changed feature fusion network for hyperspectral image change detection.

For hyperspectral images (HSI) change detection (CD), multi-scale features are usually used to construct the detection models. However, the existing studies only consider the multi-scale features containing changed and unchanged components, which is difficult to represent the subtle changes between bi-temporal HSIs in each scale. To address this problem, we propose a multi-scale diff-changed feature fusion network (MSDFFN) for HSI CD, which improves the ability of feature representation by learning the refined change components between bi-temporal HSIs under different scales. In this network, a temporal feature encoder-decoder sub-network, which combines a reduced inception module and a cross-layer attention module to highlight the significant features, is designed to extract the temporal features of HSIs. A bidirectional diff-changed feature representation module is proposed to learn the fine changed features of bi-temporal HSIs at various scales to enhance the discriminative performance of the subtle change. A multi-scale attention fusion module is developed to adaptively fuse the changed features of various scales. The proposed method can not only discover the subtle change of bi-temporal HSIs but also improve the discriminating power for HSI CD. Experimental results on three HSI datasets show that MSDFFN outperforms a few state-of-the-art methods

Retinal status analysis method based on feature extraction and quantitative grading in OCT images

Background: Optical coherence tomography (OCT) is widely used in ophthalmology for viewing the morphology of the retina, which is important for disease detection and assessing therapeutic effect. The diagnosis of retinal diseases is based primarily on the subjective analysis of OCT images by trained ophthalmologists. This paper describes an OCT images automatic analysis method for computer-aided disease diagnosis and it is a critical part of the eye fundus diagnosis. Methods: This study analyzed 300 OCT images acquired by Optovue Avanti RTVue XR (Optovue Corp., Fremont, CA). Firstly, the normal retinal reference model based on retinal boundaries was presented. Subsequently, two kinds of quantitative methods based on geometric features and morphological features were proposed. This paper put forward a retinal abnormal grading decision-making method which was used in actual analysis and evaluation of multiple OCT images. Results: This paper showed detailed analysis process by four retinal OCT images with different abnormal degrees. The final grading results verified that the analysis method can distinguish abnormal severity and lesion regions. This paper presented the simulation of the 150 test images, where the results of analysis of retinal status showed that the sensitivity was 0.94 and specificity was 0.92.The proposed method can speed up diagnostic process and objectively evaluate the retinal status. Conclusions: This paper aims on studies of retinal status automatic analysis method based on feature extraction and quantitative grading in OCT images. The proposed method can obtain the parameters and the features that are associated with retinal morphology. Quantitative analysis and evaluation of these features are combined with reference model which can realize the target image abnormal judgment and provide a reference for disease diagnosi

RNA Secondary Structure Representation Network for RNA-proteins Binding Prediction

RNA-binding proteins (RBPs) play a significant part in several biological processes in the living cell, such as gene regulation and mRNA localization. Several deep learning methods, especially the model based on convolutional neural network(CNN), have been used to predict the binding sites. However, previous methods fail to represent RNA secondary structure features. The traditional deep learning methods generally transform the RNA secondary structure to a regular matrix that cannot reveal the topological structure information of RNA. To effectively extract the structure features of RNA, we propose an RNA secondary structure representation network (RNASSR-Net) based on graph convolutional neural network (GCN) and convolution neural network (CNN) for RBP binding prediction. RNASSR-Net constructs the graph model derived from the RNA secondary structure to learn the topological properties of RNA. Then, it obtains the spatial importance of each base in RNA with CNN to guide the representation of the RNA secondary structure. Finally, RNASSR-Net combines the structure and sequence features to predict the binding sites. Experimental results demonstrate the proposed method outperforms a few state-of-the-art methods on the benchmark datasets and gets a higher improvement on the small-size data. Besides, the proposed RNASSR-Net is also used to detect the accurate motifs compared with the experimentally verified motifs, which reveals the binding region location and RNA structure interpretation for some biological guidance in the future

Dimensionality Reduction of Hyperspectral Imagery Based on Spatial-Spectral Manifold Learning

The graph embedding (GE) methods have been widely applied for dimensionality reduction of hyperspectral imagery (HSI). However, a major challenge of GE is how to choose the proper neighbors for graph construction and explore the spatial information of HSI data. In this paper, we proposed an unsupervised dimensionality reduction algorithm called spatial-spectral manifold reconstruction preserving embedding (SSMRPE) for HSI classification. At first, a weighted mean filter (WMF) is employed to preprocess the image, which aims to reduce the influence of background noise. According to the spatial consistency property of HSI, SSMRPE utilizes a new spatial-spectral combined distance (SSCD) to fuse the spatial structure and spectral information for selecting effective spatial-spectral neighbors of HSI pixels. Then, it explores the spatial relationship between each point and its neighbors to adjust the reconstruction weights to improve the efficiency of manifold reconstruction. As a result, the proposed method can extract the discriminant features and subsequently improve the classification performance of HSI. The experimental results on the PaviaU and Salinas hyperspectral data sets indicate that SSMRPE can achieve better classification results in comparison with some state-of-The-Art methods